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In HBV-related chronic hepatitis, ROS trigger DNA double-strand breaks and activate the ATM signaling pathway, which in turn activates aging-related pathways such as p53/p21 and ASK1/JNK/p38, promoting the malignant transformation of normal cells [108, 109]

(PubMed) Shaw GM, Carmichael SL, Yang W, Selvin S, Schaffer DM

The truth sits in the less exciting middle: the same molecule that shows modest, genuine promise in a 250500mg oral capsule shows no such trial evidence and real regulatory red flags in an IV drip

doi: 10.1016/j.jhep.2014.12.012 6 AnguloPKleinerDEDam-LarsenSAdamsLABjornssonESCharatcharoenwitthayaPet al