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Cell adhesion molecules and cytokines: After the occurrence of an ischemic stroke, there is growing evidence of post-reperfusion inflammation during which leukocytes are recruited with the help of adhesion molecules from the selectin family, integrins (1 and 2), and intercellular adhesion molecule-1 (ICAM-1) [113,119]

In response to the imbalance of intracellular sulfur metabolism, thiol and disulfide balance, as well as the systemic regulation of Trx and Grx and the cross-talk between cell death after the occurrence of the disease, effective interventions and treatment drugs have been explored to identify pathways and multiple approaches for treating neurodegenerative diseases

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Connective tissue then replaces degraded tissue in a process called fibroplasia or fibrosis