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Proc Am Fed Clin Res

Kinases Mst1 and Mst2 detect ROS and uphold the redox equilibrium within macrophages by modulating the stability of the antioxidant transcription factor Nrf2 (151)

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

However, in clinical practice, troublesome GERD symptoms persist in 20 30% of patients despite daily treatment with a proton pomp inhibitor (PPI)