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We characterized 61 proteins that may interact with CXCL10, among which IL18R1 was the only receptor (Fig

10.1021/jf303665z 26 LiY.WeiG.ChenJ

This led to the development of a HER2 targeted monoclonal antibody, trastuzumab, which prevents ligand association with HER2 and ablates pathway activity, significantly improving patient survival (Slamon et al., 2001