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These reverse mutations enable tumor cells to resist PARP inhibitors, resulting in treatment failure ( In HGSOC, the activation of alternative repair mechanisms is a critical component of drug resistance

Psychiatry 216 VaivaG.ThomasP.DucrocqF.FontaineM.BossV.DevosP.et al (2004)

At 3 DPI, biosynthetic processes of carbon-mediated metabolism, cell structure formation, amino acid metabolism and secondary metabolite biosynthesis were mostly enriched, indicating fast metabolic changes in the fungal cells (Fig

Procyanidin B1, procyanidin B2, and epicatechin were the three main phenolics identified by Q-TOF UPLC/MS studies from the non-anthocyanin fraction (Jeong et al., 2014a, b)