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Current strategies employed in the manipulation of gene expression for clinical purposes

Putting the evidence side by side Here is the blunt comparison: AOD 9604: 2.6 kg weight loss in 12 weeks (best result), failed six clinical trials, development terminated Semaglutide: 15 to 17 percent body weight loss over 68 weeks, FDA approved, thousands of study participants, consistent results across multiple trials There is no way to frame this comparison that puts AOD 9604 on equal footing with semaglutide when it comes to clinical evidence

Front Pharm 15:1536478 Jeong E, Willett R, Rissone A, La Spina M, Puertollano R (2024) TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress

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