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For health-related research, automated coding task needs a variety of classification systems (usually with high granularity) for use in case detection or phenotyping, thus other terminologies (e.g., SNOMED CT 76 , ORDO 67,77 , and ICD-11 in the near future 25 ) and customised terminologies (e.g., for sub-stroke phenotyping 78 ), and also see the surveys 8,79

Their work includes chronic dosing studies extending to 6 weeks, comprehensive tissue examination at necropsy, and genetic toxicology assessment using standardized protocols accepted by regulatory agencies worldwide

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A significant proportion of tested samples have exceeded safety thresholds for endotoxin contamination, which refers to bacterial byproducts that, when injected, trigger systemic inflammation or, in serious cases, septic shock