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Nitric oxide serves multiple functions in wound healing: it promotes vasodilation (widening of blood vessels), supports endothelial cell proliferation, and helps regulate the inflammatory response

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64 In serine proteases, neutrophil elastase (NE), cathepsin G and proteinase-3 destroy lung tissue by degrading ECM components, and induces epithelial cells and endothelial cells to release a variety of inflammatory factors to activate and chemoattract neutrophils to produce lung inflammation

There was a caspase-3 immunopositivity in inflammatory cells of the peribronchial tissue and interalveolar area of the IR group (Fig