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In cerebral malaria, a double-blind trial has shown that the use of corticosteroids is associated with prolongation of coma and a higher incidence of pneumonia and gastrointestinal bleeding

This process is known as titration

The CDC, following guidance from the Advisory Committee on Immunization Practices (ACIP), recommends it for: Like most vaccines, the pneumococcal shot can cause mild to moderate side effects that typically resolve within a few days