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BRONCHOALVEOLAR LAVAGE The procedure that is used to obtain inflammatory cells from the lungs, which involves injecting saline down a bronchoscope and recovering the fluid, which contains inflammatory mediators and cells, such as alveolar macrophages and neutrophils, the function of which can then be studied

While the study volunteers were older adults, who may have a specific vulnerability to lower levels of B12, co-first author Alexandra Beaudry-Richard, MSc, said that these lower levels could impact cognition to a greater extent than what we previously thought, and may affect a much larger proportion of the population than we realize. Beaudry-Richard is currently completing her doctorate in research and medicine at the UCSF Department of Neurology and the Department of Microbiology and Immunology at the University of Ottawa

Experimental validation Dose response curves and determination of IC 50 values were assessed for the 12 candidate drugs using 3-fold dilution series (see Supplementary Methods (Supplementary File 1) for more details)

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