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Furthermore, cells in several types of cancers are characterized by significant enhancement of glutathione biosynthesis, and this metabolic vulnerability has been targeted to sensitize these cancer cells to ROS-induced drugs 63

10.1016/j.biocel.2007.01.020 2 BaumannF.LeukelP.DoerfeltA.BeierC

Corradini, E., Buzzetti, E

Browning of White Adipose Tissue Third, and perhaps most fascinating, NNMT inhibition promotes browning of white adipose tissue - the conversion of white adipocytes into beige/brown adipocytes that contain numerous mitochondria and express uncoupling protein 1 (UCP1), enabling them to dissipate energy as heat through non-shivering thermogenesis