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Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity

However, Nerland et al

Blood (2010) 115(9):16906

This combination ranks among the most popular stacks for injury recovery, providing faster and more complete healing than either peptide alone according to anecdotal reports