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From Our Lecture Notes: Neuroinflammation is characterized by multiple interwoven features , including microglial activation, increased glial polarization (M1 subtype), blood-brain barrier permeability, and infiltration of peripheral immune cells

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10 Observational studies have linked traumatic life events, greater exposure to stress, and higher levels of emotional distress with increased risk of fibromyalgia, though it is unclear if these are causative factors