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Astaxanthin: Astaxanthin is a powerful antioxidant known for its ability to protect skin cells from oxidative damage caused by free radicals

Notably, this heat stroke-induced LIRI differs fundamentally from reperfusion injury in hypovolemic shock or surgical contexts: in heat stroke, reperfusion is preceded by hyperthermia-induced endothelial damage and systemic inflammatory priming, which amplify oxidative stress (e.g., xanthine oxidase activation) and neutrophil infiltration

S-glutathionylated proteins were detected by Western blot using anti-glutathione monoclonal antibody