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ShHTLs of the different clades showed distinct responses to SL, including natural SLs: strigol, 5-deoxystrigol (5DS), 4-deoxyorobanchol and sorgolactone, and a racemic mixture of the synthetic SL analog GR24 ( rac -GR24) or KAR in cross-species complementation assays, in which Arabidopsis kai2-2 and htl-3 mutants were transformed with ShHTLs genes: ShHTL1 is not responsive to KAR or SL

A randomized, placebo-controlled, double-blind trial on type 2 diabetic patients administered 600 mg/d EPA and 300 mg/d DHA supplementation for 10 wks disclosed that their Nrf2 expression levels were higher than those of placebo-treated controls [71]

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