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Lo et al., 2016)

MMA is a genetically heterogeneous disorder, with the majority (~60%) of cases caused by complete ( mut 0 ) or partial ( mut ) deficiency of the enzyme methylmalonyl-CoA mutase (MMUT) and the remainder due to errors in the synthesis or transport of 5-deoxyadenosylcobalamin, a vitamin B 12 derivative and essential cofactor of the reaction (1, 2)

Front Physiol 12:1530 Bomer N, Pavez-Giani MG, Grote Beverborg N, Cleland JGF, van Veldhuisen DJ, van der Meer P (2022) Micronutrient deficiencies in heart failure: mitochondrial dysfunction as a common pathophysiological mechanism

Most did not find significant differences between the group taking coenzyme Q 10 and the group taking placebo with respect to measures of aerobic exercise performance, such as maximal oxygen consumption (VO 2 max) and exercise time to exhaustion (86-90)