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5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC50 value (IC50=1 M), and high cell membrane permeability (Table 5), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors

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Excipients such as sorbitol, mannitol (sugar alcohols), lactose (in those with intolerance), and various binding agents or fillers may contribute to gastrointestinal symptoms