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BDC2.5 T cells upregulated both PD-1 and LAG-3 early (Day 4) after activation, however by Day 8 most untreated CD4 + T cells began to downregulate expression of the checkpoint molecules as predicted, with an even further downregulation evident by Day 14 ( Figures 5D, E ) ( Figures 5D, E )

Foaming is a visual indicator of potential peptide damage

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