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Disclosures: Zobair Younossi: Nothing to Disclose, Alexandra Ellis: Stratevi, LLC: Employee, Jackie Lee: Intercept: Employee of Stratevi, LLC, which received funding from Inter, Leona Bessonova: Nothing to Disclose, Radhika Nair: Intercept Pharma: Employee, Sanofi: Employee, Elizabeth Potente: Nothing to Disclose, Robert Gish: please see full disclosures document: Consultant 2354 IMPROVING KNOWLEDGE IN PBC MANAGEMENT BEYOND FIRST-LINE THERAPY: STRUCTURED LEARNING INCREASES COMPETENCE AND CONFIDENCE S Christy Rohani-Montez 1 Marinella Calle 1 Jrn Schattenberg 2 David Jones 3 , 1 Medscape Education Global, 2 University Medical Center Homburg, 3 Newcastle University, UK Background: Up to ~40% of patients with PBC have an inadequate response or poor tolerability to UDCA leading to an increased risk of end-stage liver disease

Figure 1 Mitoepigenetics in aging The aging process leads to nuclear epigenetic alterations such as remodelling of chromatin structure caused by changes in DNA methylation and histone PTMs, telomere shortening, and modulation of ncRNAs espression ( The effects of TFAM post-translational modifications TFAM plays an essential role in maintenance, expression, and organization of mitochondrial DNA

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