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The implantation theory on the pathogenesis of EMS indicates the key role of hypoxia in the occurrence and development of EMS, which involves cell biological processes such as apoptosis, adhesion, proliferation, invasion, and metastasis of ectopic endometrial cells

14, with lesion areas of 119 mm 2 and 111 mm 2 compared to 283 mm 2 , respectively, indicating that the transgenic lines acquired solid resistance (Muramoto et al., 2012)