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Analysis of tumor PD-L1 expression and biomarkers in relation to clinical activity in patients (pts) with deficient DNA mismatch repair (dMMR)/high microsatellite instability (MSI-H) metastatic colorectal cancer (mCRC) treated with nivolumab (NIVO) 1 ipilimumab (IPI): CheckMate 142

Among the various pro-inflammatory factors, TNF can promote the production of extracellular matrix (ECM) and regulate the proliferation and differentiation of lens epithelial cells, but the roles of other factors in cataract formation need to be further investigated

Consequently, the spatial distribution of immunoreactive ferritin-positive microglia can serve as a biological marker for the degree of labile iron accumulation in the brain parenchyma (139)

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