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eBioMedicine 72 , 103590 (2021)

Abstract As a chronic autoimmune disease with complex aetiology, rheumatoid arthritis (RA) has been demonstrated to be associated with mitochondrial dysfunction since mitochondrial dysfunction can affect the survival, activation, and differentiation of immune and non-immune cells involved in the pathogenesis of RA

After washing, cells were stained with Alexa Fluor 488conjugated anti-rabbit (1:200, Invitrogen, A-10055) and Alexa Fluor 594conjugated anti-mouse (1:200, Invitrogen, A-21207) secondary antibodies for 1 h at RT

Specifically, scientists are uncovering how viral infections, chronic inflammation, and persistent physical stress deplete the body's foundational amino acids, leading to catastrophic mitochondrial failure and unchecked oxidative stress