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10.1016/j.mcna.2018.10.014 102 ReyhaniA.McKenzieT

J Hepatol 2021;75:1346-1354

The constant release of histamine causes vasodilation and increased vascular permeability, allowing fluids to leak into the surrounding tissues, which further disrupts the skin barrier and exacerbates the systemic inflammation seen in Long COVID

However, it is known that through dietary intake and/or supplementation, antioxidants such as vitamin C, E, and carotenoids are deposited into the epidermis at higher concentrations compared with the dermis [4,5,6], which suggests the importance of inside to outside treatment of the skin