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The P-loop stabilizes the phosphate groups of the bound nucleotides, while the Switch regions form critical interfaces for interacting with effector proteins and regulatory molecules, including GTPase-activating proteins (GAPs) and GTP exchange factors (GEFs) [15]

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In a randomized controlled trial of 72 patients with type 2 diabetes and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for four months resulted in significant improvement in two out of four measures of heart rate variability compared to placebo (81)