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Initially, NOSC were isolated with a similar procedure as HOSC, however isolation of NOSC resulted in a mixed population of stromal fibroblast cells and epithelial cells

however, potential benefits are limited due to several complications that result in chronic rejection of the allograft tissue ( 2 , edema, increased pulmonary vascular resistance and enhanced vascular permeability causing immune cell infiltration and inflammation

Conversely, sets of genes we identified as significantly positively or negatively associated with Lm were examined within gene lists ranked by the degree of differential expression as determined by re-analyzing previously published COPD-or TGF-related microarray studies