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it is a severe adverse effect that can limit dose and choice of chemotherapy Many substances already approved for treating neuropathic pain failed to ameliorate CIPNP in clinical trials, underlining the importance of assessing drug efficacy in CIPNP independently of other neuropathic pain states CIPNP has distinctive mechanisms that depend on the causative cytostatic drug

Milk Thistle and Turmeric are widely used in herbal wellness formulations, while NAC and Alpha Lipoic Acid are recognized for their inclusion in antioxidant-focused nutrition products

Fermented milk products containing probiotics can regulate brain function and have a positive effect on cognitive function and metabolic status in Alzheimer's patients [161]

doi: 10.1016/j.semcancer.2023.03.008 3