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As a demonstration of this, cultured rat hippocampal neuronal cells were protected from oxidative stress with uric acid [38], and administration of uric acid 24 hours prior to middle artery occlusion also attenuated brain injury induced by acute ischemia in rats [38]

A third pathway, glucuronidation, has been speculated to compensate for this problem [40]

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In MASLD, oxidative stress, particularly associated with hepatic steatosis, triggers the activation of the NLRP3 inflammasome [185]