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Sulfation of hydroxylated aromatic amines (e.g

For instance, studies have demonstrated that chronic unpredictable mild stress (CUMS) in rodent models leads to transcriptional changes in key metabolic enzymes, thereby increasing the synthesis of hepatic fatty acids (278).Chronic stress in murine models has been linked to increased hepatic TGs and cholesterol levels, coupled with a decrease in total visceral fat (279)

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This means most of a high-dose supplement remains in the gastrointestinal tract, though the direct link to digestive symptoms is not well established