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doi: 10.1248/bpb.b15-00310 47 TotinoP

Disclosures: Tin Bo Nicholas Lam: Nothing to Disclose, Maria Paulina Ordonez: Nothing to Disclose, Amber Hildreth: Mirum Pharmaceuticals: Consultant, Ipsen Pharmaceuticals: Consultant 2514 SURFASA SCORE FOR PREDICTION OF STEROID RESPONSE IN CHILDREN AND ADOLESCENTS WITH SEVERE AUTOIMMUNE HEPATITIS SAMANNAY DAS Tamoghna Biswas 1 Rajeev Khanna 2 Anmol Anmol 3 Bikrant Biharilal Raghuvanshi 4 Vikrant Sood 4 Seema Alam 1 , 1 Institute of Liver and Biliary Sciences, 2 Additional proffessor ILBS, 3 Senior resident ILBS, 4 Associate proffessor ILBS Background: Steroids are indicated in severe autoimmune hepatitis to avert liver transplantation (LT)

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Although the competitive binding mechanism at the non-canonical site remains to be fully elucidated, our structural data show that the phosphate backbone of CTP shares binding pockets with UTP and ATP, highlighting a conserved mechanism of ligand recognition and stabilization across species