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Thiopurines are also commonly used as adjunct therapy in a step-down strategy for treating severe CD

Despite the use of TMZ for the treatment of GMB has shown some advantages, such as moderate side effects and increased life expectancy in patients, GBM frequently develops primary and secondary resistance to this drug due to the overexpression of O6-methylguanine-DNA-methyltransferase (MGMT) protein, which can repair the DNA damage induced by TMZ, thus preventing apoptosis of cancer cells and favoring tumor recurrence [15]

An inverse relationship was observed in the brain of autosomal-dominant familial AD mutation carriers between [ 11 C] d-l-deprenyl and [ 11 C] PIB PET demonstrating a high uptake of [ 11 C] d-l-deprenyl PET (that is, prominent reactive astrogliosis) already 1620 years before the onset of clinical symptoms

At low concentrations, the expected result can be seen where there is a decrease in reduced glutathione or increase in oxidized glutathione compared to a control (Song et al