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Generally, reliable quantification of MDA in biological samples, particularly in lipid-rich matrices, such as plasma or serum, is highly challenging due to (1) pre-analytical issues, such as variations in specimen collection and storage (conditions and time/duration), (2) analytical issues, such as artifactual formation of MDA during sample processing, work up and analysis, as well as comparability of the applied methods in terms of sensitivity and/or specificity [91, 92]

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