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The mechanisms do not appear to contradict each other, and some researchers have speculated that combining them could address both appetite and direct fat cell metabolism

On the other hand, GH via its stimulation of local IGF-I is important for testicular production of testosterone and spermatogenesis (79), and the local IGF-IGFBP-axis is involved in selection and growth of the primary follicle in the ovary, estradiol production and ovulation (80, 81)

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Treatment depends on the cause and severity of the deficiency