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This evidence challenges the conventional view of lactate merely as a metabolic waste product

Further, multiple DJ-1 protein members were identified in Brassica rapa , Populus trichocarpa , Arabidopsis lyrata , Phaseolus vulgaris , Citrus clementina , Ricinus communis , Capsella rubella , Thellungiella salsuginea , Medicago truncatula , Vitis vinifera , Solanum tuberosum , Solanum lycopersicum , Prunus persica , Genlisea aurea , Amborella trichopoda (Table 1)

Only sildenafil (a PDE5 inhibitor) and some TCMs show potential preventive effects in HAPH on animal models, which requires clinical validation