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These data suggest that circulating IGF-1 is critical for the modeling of bone, particularly periosteal growth (even more than linear growth, since femoral length of the LID and ALSKO mice was only slightly affected)

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Stamatelos SK, Brinkerhof CJ, Georgeopoulos SSIPG: Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and thresholddependent behavior