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The activation of AMPK in macrophages in BAL fluid improves cell swelling and NETs clearance

In another embodiment, the total amount of all Active Agents meant to influence the skin of the user, combined per dose (single use or application of a toothpaste of the invention) ranges from about 0.1 mg to about 10 g, in a further embodiment from about 1 mg to about 1 g and in still a further embodiment, the total amount of such actives per dose should range from about 1 mg to about 500 mg and in yet another embodiment, from about 1 mg to about 500 mg Alternatively, the amount of total Active Agents supporting the health, well- being and/or appearance of a users skin through the application to the oral cavity of a single dose of a toothpaste in accordance with the present invention, expressed in weight percent (wt %) can range from about 0.1 to about 20 wt %, and in another embodiment, from about 0.1 to about 10 wt % and in still a further embodiment, from about 0.1 to about 5 wt % based on the total weight of each dose of toothpaste which is intended to be applied

The study found a particularly strong enhancement of M1 polarization, accompanied by a significant increase in phagocytic activity

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