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This downregulation facilitated the dissociation of STIM1 from STING, thereby activating the non-canonical STING signaling pathway and enhancing autophagy in cortical neurons

8.4 MSCs and necroptosis Figure 3 previously illustrated the identification of STAT1 and JAK1 as contributors to the development of necroptosis

These oral agents were developed originally for treatment of symptomatic WD, but their role has evolved to include asymptomatic patients and longterm maintenance therapy