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Michael DEmden: Has received honoraria for attendance at national advisory boards, presentations and/or support to attend international meetings from Boehringer Ingelheim, Eli Lilly, AstraZeneca, Novartis, Abbott, Novo Nordisk, Servier and Bayer

Qiu and Kao 2003

The treatment effect was correlated with baseline tHcy levels, and even those patients with high baseline tHcy levels had cognitive decline and clinical status improvement

These include widespread inflammation which impacts sensory nerve pain, metabolic changes, leaky blood and lymphatic vessels, tissue hypoxia, presence of VEGF (which stimulates new, but abnormal blood vessel growth), and abnormal quantity and size of fat cells