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TGF is a pleiotropic cytokine that acts as a tumour suppressor in normal and dysplastic cells but switches into a tumour promoter in advanced tumours

These animals are fed a high-fat diet until they become obese, then randomized to receive either 5-amino-1mq or a control treatment

To validate that this synergistic interaction is indeed dependent on mut-p53 and SLC7A11 expression, we next demonstrated that these drug combinations were more effective in H1299 cells overexpressing mut-p53 compared to the p53 Null parental line (Fig