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196 Due to its poor bioavailability, however, NAC must be administered in fairly high doses and requires a long treatment time in patients with severe APAP overdose, thereby increasing the risk of an anaphylactoid reaction (i.e., nonimmunologic anaphylaxis), fluid overload, and high fluid osmolarity

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Although MSG has proven its value as an enhancer of flavor and popular food additive, several studies have indicated possible toxic effects on the induction of metabolic changes, which can lead to major disturbances including obesity, hepatic damages, CNS (central nervous system), and reproductive disorders