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164 Although these facts suggest that hemostatic problems are common in patients with liver disease, discordance is often noted between degree of abnormality of laboratory tests of coagulation and clinical evidence of bleeding.260,446,455 Even in patients bleeding from esophageal varices and having prolonged clotting times, administration of blood components (including activated factor VII) was not associated with any clinical difference in degree of bleeding or need for blood transfusions

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Although fatty acid oxidation produces pro- and anti-inflammatory signals immediately after injury, anti-inflammatory and vasodilatory signals persist in serum after proinflammatory octadecanoids and eicosanoids are cleared [89]

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