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These arguments are largely based on rodent studies, which have found that prolonged fasting can reduce serum IGF-1 by up to 40% (18)

While that's substantially higher than the 600mg starting dose we generally favor for people new to NAC, it reflects the GlyNAC protocols studied in healthy-aging research.34 57 58 Some readers may prefer to start with a smaller serving for tolerability, but the clinical research on GlyNAC has generally evaluated gram-level doses of both ingredients, so it's unclear whether substantially lower amounts would provide the same benefits

It is crucial to emphasize that the negative effects identified in Botox clinical studies occurred while the medicine was used for FDA-approved purposes