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[12]Current Patent Assignee: MERCK SHARP DOHME - WO2023/158626, 2023, A1 Location in patent: Page/Page column 88

Expected timeline: Week 1-2: Initial subtle improvements, possible temporary increase in awareness of issues Week 3-4: Noticeable reduction in chronic tension patterns Week 5-8: Progressive improvement, better response to stretching and exercise Week 8-12: Significant resolution, establishing new baseline Complementary approaches: Physical therapy or targeted stretching

The same is probably true of the human enzyme

High doses might also possibly interfere with levels of other vitamins, enzymes and minerals, which is always a potential problem when taking any nutrient in very large quantities