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10.1016/j.biocon.2016.07.013 81 GomaaM

Wolstenholme and Gardner 1950)

It is indicated that renal tissues in the MetS population predominantly exhibit chronic lesions, including varying degrees of glomerulosclerosis, tubular atrophy, interstitial fibrosis, and atherosclerosis (44, 45)

6.1.2.2 Primary efficacy results Clinical results demonstrated that compared to placebo, once-daily 10 mg or 25 mg brensocatib significantly extended time to first acute exacerbation