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It also activates the PI3K/PKB/Akt pathway, influencing cell functions [10-11]

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Although pain has never been considered a primary symptom of PD, several researchers, including Charcot 17 , had already referred to painful aspects of the disease: Sometimes Parkinson's is preceded by neuralgic or rheumatoid pains, which are occasionally of great intensity, being located in the extremity (...) that will soon be affected (...) by the convulsive agitation