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A cell with an "increased inflammatory phenotype" is one that has a greater ability to pro-inflammatory response following modulation of at least one biomarker of the invention (e.g., at least one target listed in table 1 and/or table 2) associated with: a) an increase in one or more of the listed type 1 criteria

The hoarseness of nodules typically worsens with voice use, or during a cold or sore throat, and improves with voice rest

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Additionally, the powder has a silky texture that melts