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134 Therefore, CK2 inhibitor has been considered as an indirect inhibitor of claudin-2 (Figure 3b)

Capoccia et al., 2009)

Multiple clinical studies have shown that individuals with the MetALD phenotypedefined by the coexistence of metabolic dysfunction and alcohol consumptionexhibit significantly higher levels of transaminases, fibrotic markers (e.g., PIIINP, TIMP-1), and oxidative stress biomarkers than those with MASLD alone, suggesting a synergistic effect of alcohol on fibrotic progression [38,51]

Comment on A theory of macromolecular chemotaxis and Phenomena associated with gel-water interfaces: Analyses and alternatives to a long-range ordered water hypothesis