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10.1016/j.tibs.2006.11.006 14 BrachsS.PolackJ.BrachsM.Jahn-HofmannK.ElvertR.PfenningerA.et al (2019)

We then asked how SHGs become globe- or comma-shaped granules

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In response to extrinsic stimuli, inositol 1,4,5-trisphosphate (IP 3 ) and ryanodine receptors release Ca 2+ from the ER to the cytosol, whereas the sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) pumps Ca 2+ against the gradient to maintain a concentration difference between the ER lumen and the cytosol at rest