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(2020) found that a lower dose of roxadustat (12.5 mg/kg/day) had no effect on the mRNA expression of profibrogenic molecules regardless of the 3- or 7-day trial

Therefore, lipid-overloaded macrophages turn into foam cells, which is one of the earliest cellular hallmarks of the atherosclerotic process (Jin et al., 2018)

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As a cofactor, iron regulates the activity of iron-requiring enzymes by forming redox-active (loosely-bound) and redox-silent complexes, thereby playing a complex role in oxidative stress