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This essential vitamin exists in two biologically active forms, methyl cobalamin, an indispensable cytosolic cofactor for methionine synthetase, and the mitochondrially required adenosyl cobalamin, a critical cofactor for methylmalonyl coenzyme A mutase (MMCM) [2]

The retina is especially vulnerable to oxidative stress due to its high oxygen exposure and high concentration of polyunsaturated fatty acids

and 2) cancer cells exhibit a spectrum of sensitivity to glucose deprivation 12

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