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GSSG is a product of the oxidation of GSH, which has no biological activity and needs to be reduced to GSH by consuming energy under the action of enzymes in order to resume its function

Fluid retention, joint pain, and muscle aches can also happen because of GH-related fluid shifts

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Because the release stays pulse-like rather than a constant flood, the body's own feedback loops are largely preserved, which is part of why this combo is considered a more physiologic approach than synthetic HGH